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... The presence of a functional  p53 
Mutant p53 and MDM2 in Cancer
The p53-Mdm2 Loop: A Critical Juncture of Stress Response
Levav-Cohen, Yaara; Goldberg, Zehavit; Tan, Kah Hin; Alsheich-Bartok, Osnat; Zuckerman, Valentina; Haupt, Sue; Haupt, Ygal
protein is a key factor for the proper ...
... by this role of nucleoli is the tumor suppressor  p53 
Cellular and Molecular Life Sciences
Nucleolar control of p53: a cellular Achilles’ heel and a target for cancer therapy
Vlatković, Nikolina; Boyd, Mark T.; Rubbi, Carlos P.
, which is activated in response to diverse ...
... point mutation of TP53 or through disruption of  p53 
Molecular Determinants of Head and Neck Cancer
p53 in Head and Neck Cancer
Roh, Jong-Lyel; Koch, Wayne M.
protein function as a consequence of oncogenic ...
... Background MCT-1 oncoprotein accelerates  p53 
Molecular Cancer
The antagonism between MCT-1 and p53 affects the tumorigenic outcomes
Kasiappan, Ravi; Shih, Hung-Ju; Wu, Meng-Hsun; Choy, ChikOn; Lin, Tai-Du; Chen, Linyi; Hsu, Hsin-Ling
protein degradation via a proteosome pathway. ...
... in the genesis and progression of cancer, mutant  p53 
Mutant p53 and MDM2 in Cancer
Mutant p53 and the Response to Chemotherapy and Radiation
Tchelebi, Leila; Ashamalla, Hani; Graves, Paul R.
also appears to play a significant role in the ...
... The  p53 
Signaling Pathways in Liver Diseases
Tsai, Wen-Wei; Barton, Michelle Craig
tumor suppressor is well known as the major ...
... The tumor suppressor  p53 
Mutant p53 and MDM2 in Cancer
Targeting p53-MDM2-MDMX Loop for Cancer Therapy
Zhang, Qi; Zeng, Shelya X.; Lu, Hua
plays a central role in anti-tumorigenesis and ...
... Mutations in the TP53 gene or the  p53 
CNS Cancer
p53 Pathway Alterations in Brain Tumors
Yin, Shaoman; Van Meir, Erwin G.
pathway are required for the formation of many ...
... Loss of function of  p53 
Small molecule compounds targeting the p53 pathway: are we finally making progress?
Yu, Xin; Narayanan, Sumana; Vazquez, Alexei; Carpizo, Darren R.
, either through mutations in the gene or through ...
... Most tumors inactivate the  p53 
p53 in the Clinics
Mutant p53-Driven Tumorigenesis
Terzian, Tamara; Lozano, Guillermina
tumor suppressor pathway via single nucleotide ...
... Reinstatement of the  p53 
p53 in the Clinics
p53-Reactivating Molecules as Research Tools and Anticancer Drugs
Grinkevich, Vera V.; Warnecke, Andreas; Selivanova, Galina
tumor suppressor function in cancers by small ...
... Understanding the mechanism underlying  p53 
Journal of Neuro-Oncology
Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes
Amano, Toshiyuki; Nakamizo, Akira; Mishra, Sandip K.; Gumin, Joy; Shinojima, Naoki; Sawaya, Raymond; Lang, Frederick F.
’s ability to induce cell cycle arrest versus ...
... findings suggesting a pro-oncogenic role for  p53 
Mutant p53 and MDM2 in Cancer
Cooperation of p53 Mutations with Other Oncogenic Alterations in Cancer
Girardini, Javier E.; Walerych, Dawid; Sal, Giannino
point mutants, more than 30 years of research ...
... in each subtype, alterations of tumor suppressor  p53 
Tumor Biology
Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme
England, Bryant; Huang, Tiangui; Karsy, Michael
are the most common, seen in 25–30 % of primary ...
...  p53 
Cell Senescence
Senescence Regulation by the p53 Protein Family
Qian, Yingjuan; Chen, Xinbin
, a guardian of the genome, exerts its tumor ...
...  p53 
Signal Transduction: Pathways, Mechanisms and Diseases
Activation of the p53 Tumor Suppressor and its Multiple Roles in Cell Cycle and Apoptosis
Giono, Luciana E.; Manfredi, James J.
is a widely conserved tumor suppressor protein ...
...  p53 
Targeting p53 for enhanced radio- and chemo-sensitivity
Lu, Chao; El-Deiry, Wafik S.
acts as a central mediator of the cellular ...
... recent evidence suggests that tumour suppressor  p53 
Mitochondria: The Anti- cancer Target for the Third Millennium
Crosstalk Between p53 and Mitochondrial Metabolism
Itahana, Koji; Pervaiz, Shazib
actively participates in these communications. ...
... Background The tumor suppressor gene  p53 
Molecular Cancer
Expression of full-length p53 and its isoform Δp53 in breast carcinomas in relation to mutation status and clinical parameters
Baumbusch, Lars; Myhre, Simen; Langerød, Anita; Bergamaschi, Anna; Geisler, Stephanie; Lønning, Per; Deppert, Wolfgang; Dornreiter, Irene; Børresen-Dale, Anne-Lise
(TP53) controls numerous signaling pathways and ...
...  p53 
25 Years of p53 Research
Regulation of p53 DNA Binding
McKinney, Kristine; Prives, Carol
is one of the most frequently mutated genes in ...
... The  p53 
Lung Cancer
Clinical Implications of p53 Mutations in Lung Cancer
Campling, Barbara G.; El-Deiry, Wafik S.
tumor-suppressor gene plays a crucial role in the ...
...  p53 
Mutant p53 and MDM2 in Cancer
p53: Its Mutations and Their Impact on Transcription
Vaughan, Catherine; Pearsall, Isabella; Yeudall, Andrew; Deb, Swati Palit; Deb, Sumitra
is a tumor suppressor protein whose key function ...
... No summary available 1 The  p53 
Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy
p53 Inhibitors as Cancer Sensitizing Agents
Maina, Flavio; Dono, Rosanna
Player: A Stage Director for the Fate of Stressed ...
... Introduction Normal function of the  p53 
Breast Cancer Research
p53 mutant breast cancer patients expressing p53γ have as good a prognosis as wild-type p53 breast cancer patients
Bourdon, Jean-Christophe; Khoury, Marie P; Diot, Alexandra; Baker, Lee; Fernandes, Kenneth; Aoubala, Mustapha; Quinlan, Philip; Purdie, Colin A; Jordan, Lee B; Prats, Anne-Catherine; Lane, David P; Thompson, Alastair M
network is lost in most cancers, often through ...
... Background The  p53 
Biology Direct
Impact of Alu repeats on the evolution of human p53 binding sites
Cui, Feng; Sirotin, Michael V; Zhurkin, Victor B
tumor suppressor protein is involved in a ...