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... Understanding the mechanism underlying  p53 
Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes
Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes
Amano, Toshiyuki; Nakamizo, Akira; Mishra, Sandip K.; Gumin, Joy; Shinojima, Naoki; Sawaya, Raymond; Lang, Frederick F.
’s ability to induce cell cycle arrest versus ...
... by this role of nucleoli is the tumor suppressor  p53 
Nucleolar control of p53: a cellular Achilles’ heel and a target for cancer therapy
Nucleolar control of p53: a cellular Achilles’ heel and a target for cancer therapy
Vlatković, Nikolina; Boyd, Mark T.; Rubbi, Carlos P.
, which is activated in response to diverse ...
... In this work we present evidence that the  p53 
Modulation of p53 activity by IκBα: Evidence suggesting a common phylogeny between NF-κB and p53 transcription factors
Modulation of p53 activity by IκBα: Evidence suggesting a common phylogeny between NF-κB and p53 transcription factors
Dreyfus, David H; Nagasawa, Masayuki; Gelfand, Erwin W; Ghoda, Lucy Y
tumor suppressor protein and NF-κB transcription ...
... point mutation of TP53 or through disruption of  p53 
p53 in Head and Neck Cancer
p53 in Head and Neck Cancer
Roh, Jong-Lyel; Koch, Wayne M.
protein function as a consequence of oncogenic ...
... Background MCT-1 oncoprotein accelerates  p53 
The antagonism between MCT-1 and p53 affects the tumorigenic outcomes
The antagonism between MCT-1 and p53 affects the tumorigenic outcomes
Kasiappan, Ravi; Shih, Hung-Ju; Wu, Meng-Hsun; Choy, ChikOn; Lin, Tai-Du; Chen, Linyi; Hsu, Hsin-Ling
protein degradation via a proteosome pathway. ...
... in the genesis and progression of cancer, mutant  p53 
Mutant p53 and the Response to Chemotherapy and Radiation
Mutant p53 and the Response to Chemotherapy and Radiation
Tchelebi, Leila; Ashamalla, Hani; Graves, Paul R.
also appears to play a significant role in the ...
... The tumor suppressor  p53 
Targeting p53-MDM2-MDMX Loop for Cancer Therapy
Targeting p53-MDM2-MDMX Loop for Cancer Therapy
Zhang, Qi; Zeng, Shelya X.; Lu, Hua
plays a central role in anti-tumorigenesis and ...
... Background The  p53 
Impact of Alu repeats on the evolution of human p53 binding sites
Impact of Alu repeats on the evolution of human p53 binding sites
Cui, Feng; Sirotin, Michael V; Zhurkin, Victor B
tumor suppressor protein is involved in a ...
... The presence of a functional  p53 
The p53-Mdm2 Loop: A Critical Juncture of Stress Response
The p53-Mdm2 Loop: A Critical Juncture of Stress Response
Levav-Cohen, Yaara; Goldberg, Zehavit; Tan, Kah Hin; Alsheich-Bartok, Osnat; Zuckerman, Valentina; Haupt, Sue; Haupt, Ygal
protein is a key factor for the proper ...
... Reinstatement of the  p53 
p53-Reactivating Molecules as Research Tools and Anticancer Drugs
p53-Reactivating Molecules as Research Tools and Anticancer Drugs
Grinkevich, Vera V.; Warnecke, Andreas; Selivanova, Galina
tumor suppressor function in cancers by small ...
... findings suggesting a pro-oncogenic role for  p53 
Cooperation of p53 Mutations with Other Oncogenic Alterations in Cancer
Cooperation of p53 Mutations with Other Oncogenic Alterations in Cancer
Girardini, Javier E.; Walerych, Dawid; Sal, Giannino
point mutants, more than 30 years of research ...
...  p53 
Exonucleolytic degradation of RNA by p53 protein in cytoplasm
Exonucleolytic degradation of RNA by p53 protein in cytoplasm
Bakhanashvili, Mary; Gedelovich, Rachel; Grinberg, Shai; Rahav, Galia
in cytoplasm displays an intrinsic 3′→5′ ...
... of the Forkhead box (Fox; Sect. 10.9.3) and  P53 
Other Major Types of Signaling Mediators
Other Major Types of Signaling Mediators
Thiriet, Marc
families (Sect. 10.9.4; Table 10.1). Other ...
...  p53 
Mice defective in p53 nuclear localization signal 1 exhibit exencephaly
Mice defective in p53 nuclear localization signal 1 exhibit exencephaly
Regeling, Anouk; Armata, Heather L.; Gallant, Judy; Jones, Stephen N.; Sluss, Hayla K.
is a major suppressor of human malignancy. ...
... The tumour suppressor  p53 
The role of DNA damage responses in p53 biology
The role of DNA damage responses in p53 biology
Speidel, Daniel
is a central player in cellular DNA damage ...
... The  p53 
p53
p53
Tsai, Wen-Wei; Barton, Michelle Craig
tumor suppressor is well known as the major ...
... no curative treatments. While mutation of the  P53 
P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation
P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation
Avery-Kiejda, Kelly A; Bowden, Nikola A; Croft, Amanda J; Scurr, Lyndee L; Kairupan, Carla F; Ashton, Katie A; Talseth-Palmer, Bente A; Rizos, Helen; Zhang, Xu D; Scott, Rodney J; Hersey, Peter
tumour suppressor gene is a common feature of ...
... tumor suppressor in multicellular organisms,  p53 
p53
p53
Alexieva-Botcheva, Krassimira; Anderson, Carl W.
arguably is one of the most intensively studied ...
... of Alzheimer's disease. The transcription factor,  p53 
GSK3 and p53 - is there a link in Alzheimer's disease?
GSK3 and p53 - is there a link in Alzheimer's disease?
Proctor, Carole J; Gray, Douglas A
also plays a role and has been linked to an ...
...  p53 
Activation of the p53 Tumor Suppressor and its Multiple Roles in Cell Cycle and Apoptosis
Activation of the p53 Tumor Suppressor and its Multiple Roles in Cell Cycle and Apoptosis
Giono, Luciana E.; Manfredi, James J.
is a widely conserved tumor suppressor protein ...
... MTI-induced cell death. Especially, the role of  p53 
p53 acetylation enhances Taxol-induced apoptosis in human cancer cells
p53 acetylation enhances Taxol-induced apoptosis in human cancer cells
Kim, Jae Hyeong; Yoon, Eun-Kyung; Chung, Hye-Jin; Park, Seong-Yeol; Hong, Kyeong-Man; Lee, Chang-Hun; Lee, Yeon-Su; Choi, Kyungho; Yang, Young; Kim, Kyungtae; Kim, In-Hoo
in this process has been controversial for a long ...
... The human mutant  p53 
Lung specific expression of a human mutant p53 affects cell proliferation in transgenic mice
Lung specific expression of a human mutant p53 affects cell proliferation in transgenic mice
Duan, Wenrui; Gao, Li; Jin, David; Otterson, Gregory A.; Villalona-Calero, Miguel A.
(273H) has been shown in vitro to have both ...
... in each subtype, alterations of tumor suppressor  p53 
Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme
Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme
England, Bryant; Huang, Tiangui; Karsy, Michael
are the most common, seen in 25–30 % of primary ...
... harbor mutations in the tumor suppressor  p53 
Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis
Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis
Chander, Harish; Brien, Colin D; Truesdell, Peter; Watt, Kathleen; Meens, Jalna; Schick, Colleen; Germain, Doris; Craig, Andrew WB
, we tested whether ...
... accumulation of PTEN and its interaction with  p53 
Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma
Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma
Das, Ranjita; Bhattacharya, Kaushik; Sarkar, Sayantani; Samanta, Suman Kumar; Pal, Bikas C.; Mandal, Chitra
/p73. ...