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... The presence of a functional  p53 
The p53-Mdm2 Loop: A Critical Juncture of Stress Response
The p53-Mdm2 Loop: A Critical Juncture of Stress Response
Levav-Cohen, Yaara; Goldberg, Zehavit; Tan, Kah Hin; Alsheich-Bartok, Osnat; Zuckerman, Valentina; Haupt, Sue; Haupt, Ygal
protein is a key factor for the proper ...
... by this role of nucleoli is the tumor suppressor  p53 
Nucleolar control of p53: a cellular Achilles’ heel and a target for cancer therapy
Nucleolar control of p53: a cellular Achilles’ heel and a target for cancer therapy
Vlatković, Nikolina; Boyd, Mark T.; Rubbi, Carlos P.
, which is activated in response to diverse ...
... point mutation of TP53 or through disruption of  p53 
p53 in Head and Neck Cancer
p53 in Head and Neck Cancer
Roh, Jong-Lyel; Koch, Wayne M.
protein function as a consequence of oncogenic ...
... Background MCT-1 oncoprotein accelerates  p53 
The antagonism between MCT-1 and p53 affects the tumorigenic outcomes
The antagonism between MCT-1 and p53 affects the tumorigenic outcomes
Kasiappan, Ravi; Shih, Hung-Ju; Wu, Meng-Hsun; Choy, ChikOn; Lin, Tai-Du; Chen, Linyi; Hsu, Hsin-Ling
protein degradation via a proteosome pathway. ...
... The tumour suppressor  p53 
The role of DNA damage responses in p53 biology
The role of DNA damage responses in p53 biology
Speidel, Daniel
is a central player in cellular DNA damage ...
... in the genesis and progression of cancer, mutant  p53 
Mutant p53 and the Response to Chemotherapy and Radiation
Mutant p53 and the Response to Chemotherapy and Radiation
Tchelebi, Leila; Ashamalla, Hani; Graves, Paul R.
also appears to play a significant role in the ...
... The  p53 
p53
p53
Tsai, Wen-Wei; Barton, Michelle Craig
tumor suppressor is well known as the major ...
... The tumor suppressor  p53 
Targeting p53-MDM2-MDMX Loop for Cancer Therapy
Targeting p53-MDM2-MDMX Loop for Cancer Therapy
Zhang, Qi; Zeng, Shelya X.; Lu, Hua
plays a central role in anti-tumorigenesis and ...
... Mutations in the TP53 gene or the  p53 
p53 Pathway Alterations in Brain Tumors
p53 Pathway Alterations in Brain Tumors
Yin, Shaoman; Van Meir, Erwin G.
pathway are required for the formation of many ...
... The  p53 
The p53 Transcription Factor as Therapeutic Target in Cancer
The p53 Transcription Factor as Therapeutic Target in Cancer
Asker, C.; Bykov, V. J. N.; Mendez-Vidal, C.; Selivanova, G.; Wilhelm, M. T.; Wiman, K. G.
tumor suppressor protein is a transcription ...
... Loss of function of  p53 
Small molecule compounds targeting the p53 pathway: are we finally making progress?
Small molecule compounds targeting the p53 pathway: are we finally making progress?
Yu, Xin; Narayanan, Sumana; Vazquez, Alexei; Carpizo, Darren R.
, either through mutations in the gene or through ...
... The  p53 
p53 at the Crossroads Between Stress Response Signaling and Tumorigenesis: From Molecular Mechanisms to Therapeutic Opportunities
p53 at the Crossroads Between Stress Response Signaling and Tumorigenesis: From Molecular Mechanisms to Therapeutic Opportunities
Giono, Luciana E.; Ladelfa, M. Fátima; Monte, Martín
tumor suppressor is a transcription factor that ...
... Most tumors inactivate the  p53 
Mutant p53-Driven Tumorigenesis
Mutant p53-Driven Tumorigenesis
Terzian, Tamara; Lozano, Guillermina
tumor suppressor pathway via single nucleotide ...
... Reinstatement of the  p53 
p53-Reactivating Molecules as Research Tools and Anticancer Drugs
p53-Reactivating Molecules as Research Tools and Anticancer Drugs
Grinkevich, Vera V.; Warnecke, Andreas; Selivanova, Galina
tumor suppressor function in cancers by small ...
... Understanding the mechanism underlying  p53 
Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes
Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes
Amano, Toshiyuki; Nakamizo, Akira; Mishra, Sandip K.; Gumin, Joy; Shinojima, Naoki; Sawaya, Raymond; Lang, Frederick F.
’s ability to induce cell cycle arrest versus ...
... findings suggesting a pro-oncogenic role for  p53 
Cooperation of p53 Mutations with Other Oncogenic Alterations in Cancer
Cooperation of p53 Mutations with Other Oncogenic Alterations in Cancer
Girardini, Javier E.; Walerych, Dawid; Sal, Giannino
point mutants, more than 30 years of research ...
... The  p53 
The p53 Tumor Suppressor Gene: Structure, Function and Mechanism of Action
The p53 Tumor Suppressor Gene: Structure, Function and Mechanism of Action
Choisy-Rossi, Caroline; Reisdorf, Philippe; Yonish-Rouach, Elisheva
protein was first identified through its ability ...
... In this work we present evidence that the  p53 
Modulation of p53 activity by IκBα: Evidence suggesting a common phylogeny between NF-κB and p53 transcription factors
Modulation of p53 activity by IκBα: Evidence suggesting a common phylogeny between NF-κB and p53 transcription factors
Dreyfus, David H; Nagasawa, Masayuki; Gelfand, Erwin W; Ghoda, Lucy Y
tumor suppressor protein and NF-κB transcription ...
... in each subtype, alterations of tumor suppressor  p53 
Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme
Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme
England, Bryant; Huang, Tiangui; Karsy, Michael
are the most common, seen in 25–30 % of primary ...
...  p53 
Senescence Regulation by the p53 Protein Family
Senescence Regulation by the p53 Protein Family
Qian, Yingjuan; Chen, Xinbin
, a guardian of the genome, exerts its tumor ...
...  p53 
Activation of the p53 Tumor Suppressor and its Multiple Roles in Cell Cycle and Apoptosis
Activation of the p53 Tumor Suppressor and its Multiple Roles in Cell Cycle and Apoptosis
Giono, Luciana E.; Manfredi, James J.
is a widely conserved tumor suppressor protein ...
...  p53 
Targeting p53 for enhanced radio- and chemo-sensitivity
Targeting p53 for enhanced radio- and chemo-sensitivity
Lu, Chao; El-Deiry, Wafik S.
acts as a central mediator of the cellular ...
... recent evidence suggests that tumour suppressor  p53 
Crosstalk Between p53 and Mitochondrial Metabolism
Crosstalk Between p53 and Mitochondrial Metabolism
Itahana, Koji; Pervaiz, Shazib
actively participates in these communications. ...
... harbor somatic mutations of the tumor suppressor  p53 
New perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy
New perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy
Guo, Gang; Cui, Yan
( ...
... The  p53 
Clinical Implications of p53 Mutations in Lung Cancer
Clinical Implications of p53 Mutations in Lung Cancer
Campling, Barbara G.; El-Deiry, Wafik S.
tumor-suppressor gene plays a crucial role in the ...